منابع مشابه
Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal, valproate induced hepatotoxicity.
Reduced hepatic mitochondrial beta-oxidation and changes in the plasma carnitine pool are important biochemical findings in valproate induced liver toxicity. The carnitine pools in plasma and liver and the liver coenzyme A (CoA) pool in a patient with fatal, valproate induced hepatotoxicity were measured. In plasma and liver the free and total carnitine contents were decreased, whereas the rati...
متن کاملFatal hepatotoxicity induced by hydralazine or labetalol.
Antihypertensive agents have been associated with adverse reactions that, if unrecognized by health practitioners, may have devastating consequences. The pattern of hepatotoxicity observed during therapy with the vasodilator hydralazine is highly variable, often making its diagnosis difficult. Serious hepatic injury induced by the alpha- and beta-adrenergic receptor antagonist labetalol has onl...
متن کاملNimesulide-induced hepatotoxicity and fatal hepatic failure.
Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 (cox-2) inhibitors are structurally heterogeneous drugs that share similar therapeutic actions and adverse effects. Hepatotoxicity, although a relatively rare adverse effect of this class of drugs, can be severe. This has led to the withdrawal of some NSAIDs from the market. Nimesulide is an NSAID, with cox-2 preference, which...
متن کاملHepatotoxicity to sodium valproate: a review.
Since 1978 a number of reports have indicated a possible association between sodium valproate therapy and the occurrence of hepatitis. In this review we have analysed, with particular reference to the clinical presentation, course and coadministration of other drugs, the 42 cases with fatal hepatitis either known to the manufacturers or reported elsewhere,'11 and the more frequent cases with mi...
متن کاملFatal isoflurane hepatotoxicity without re-exposure.
Isoflurane is less hepatotoxic than its predecessors, halothane and enflurane. We present a 68-year-old man who developed fulminant and fatal hepatic necrosis two days after open cholecystectomy done under isoflurane anesthesia. Laboratory findings included grossly elevated transaminases and bilirubin and prolonged prothrombin time. Serological studies were negative for viral hepatitis. Postmor...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1993
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-7-8-10